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Would you recognize a patient with GL ?
Physical features are important diagnostic indicators of generalized lipodystrophy (GL).2
Typical Presenting Features
Generalized lack of subcutaneous fat with muscular appearance, acromegaloid features, and umbilical prominence 1,2
Generalized subcutaneous fat loss that is usually insidious (over years) but can sometimes be rapid (over weeks); more common in females 1,2
Consider generalized lipodystrophy (GL) in your differential diagnosis2
- Currently, there are no defined serum leptin levels to establish a diagnosis of GL. 2
- Although firm diagnostic criteria have not been established for GL, there is consensus that a group of clinical characteristics should raise the suspicion of GL.
The figure below highlights those key clinical characteristics.1,2,12